Senior Staff Scientist @ Sanger Institute
Senior Lecturer @ University of Bath
Leading the Global Pneumococcal Sequencing project, inform vaccine design and promote equality in science
Stephanie Lo
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However, this promoter variant does not thrive on its own and is usually co-occurence of the wild-type promoter without "A", showing heterogeneous gene expression during single infections provides population benefits.
This tiny mutation—found not only mouse colonization models but also clinical isolates from the #GPS_project — enhance S. pneumoniae colonization reducing mucus trapping.
[New paper alert 🚨 ] What happens when pneumococci 'slip' and 'add' just one extra A in a promoter spacer of a sugar scavenging gene? 🧬
www.cell.com/cell-host-mi...
A great collaboration with Dr Dan Neill and his team at University of Dundee and scientists from UCL, St. Jude Children's Research Hospital, Uni of Bern, Uni of Liverpool, Uni of Cape Town, Uni of Western Australia, Uni of Bath, Milner centre for Evolution and @sangerinstitute.bsky.social
[🚨New Paper 🚨]SeroBA recognised 102/107 known pneumococcal serotypes and its companion resources webpage SeroBAnk are now published on Microbial Genomics @microbiologysociety.org
www.microbiologyresearch.org/content/jour...
[🚨Data release🚨] The #GPS_project database Monocle is now having 40k pneumococcal genomes and detailed metadata !
Thanks @HarryHung at @sangerinstitute and Simran Utreja at CDC to put them together!
data-viewer.monocle.sanger.ac.uk/project/gps
