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Senior Staff Scientist @ Sanger Institute Senior Lecturer @ University of Bath Leading the Global Pneumococcal Sequencing project, inform vaccine design and promote equality in science
Stephanie Lo
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[🚨Data release🚨] The #GPS_project database Monocle is now having 40k pneumococcal genomes and detailed metadata ! Thanks @HarryHung at @sangerinstitute and Simran Utreja at CDC to put them together! data-viewer.monocle.sanger.ac.uk/project/gps
However, this promoter variant does not thrive on its own and is usually co-occurence of the wild-type promoter without "A", showing heterogeneous gene expression during single infections provides population benefits.
This tiny mutation—found not only mouse colonization models but also clinical isolates from the #GPS_project — enhance S. pneumoniae colonization reducing mucus trapping.