Proud to see this published in @cidjournal.bsky.social & with an accompanying commentary!ย
Nasal decolonization = IP tool
MRSA nares = Abx stewardship tool
but what happens when they intersect?ย
Decolonization doesnโt limit usefulness of PCR testing within the first week!
Excited to share an article that I've long awaited to share seeking to answer: What is the right dose of cephalexin/cefadroxil for SSTIs?
We reviewed clinical studies & conducted PTA sims to elucidate this #IDSky @absteward.bsky.social
accpjournals.onlinelibrary.wiley.com/doi/10.1002/...
Evaluation of the impact of universal mupirocin decolonization in intensive care units on the utility of MRSA PCR nasal swab testing
โ Just Accepted
๐ https://bit.ly/4bWBN9b
What's Hot This Year in ID Clinical Science 2025
โ Just Accepted
๐ https://bit.ly/4t0iXEH
๐ฅJust published ๐ฅNEJM
SNAP RCT
In patients with MSSA bacteremia, cefazolin was noninferior to flucloxacillin or cloxacillin with respect to 90-day mortality and was associated with a lower incidence of acute kidney injury. #idsky
www.nejm.org/doi/full/10....
Burden of Injection Drug Use-Related Infection Hospitalizations in Tennessee, 2016โ2023
โ Just Accepted
๐ https://bit.ly/4c6Fh7Z
New on Vumedi: Dr. Jeffrey Freiberg discusses findings from the STOP-Vanc trial and the role of MRSA PCR nasal swab testing in guiding vancomycin de-escalation for ICU patients with suspected pneumonia.
Watch Now: www.vumedi.com/video/de-esc...
#InfectiousDiseases #AntimicrobialStewardship
My thesis work has been a wealth of experience in #hostmicrobe biology, #MicrobialGenetics, and @microbesinfo.bsky.social that I look forward to sharing later this week! Thank you to the #mentors, collegaues, and #collaborators that worked with me the last 4 years! DM/comment for Zoom info!
The NPV of MRSA PCR nasal swabs is not diminished after mupirocin decolonization. MRSA PCR testing within 7 days of initiation of decolonization is non-inferior to testing prior to decolonization.
Optimal cephalexin and cefadroxil dosing for skin and soft tissue infections (SSTIs) is unclear. We summarize clinical and pharmacokinetic/pharmacodynamic (PK/PD) data that compare dosing strategies ...
Staphylococcus aureus bacteremia is associated with high mortality. Whether cefazolin or an antistaphylococcal penicillin should be preferred for the treatment of methicillin-susceptible S. aureus ...
In this session, Dr. Jeffrey Freiberg reviews findings from the Swab Testing to Optimize Pneumonia Treatment With Empiric Vancomycin (STOP-Vanc) randomized controlled trial. He explores the role of MR...
In Tennessee, hospitalizations for injection-related infections disproportionately affected eastern Tennessee, and plateaued in 2018. Hospitalizations for
Kinda Surprising!
๐๐ฅ๐ขSTOP-Vanc RCT
MRSA PCR nasal swab testing did not decrease the duration of vancomycin use or 30d mortality among ICU patients with suspected CAP,despite MRSA PCR nasal swab testing demonstrating a high NPV #idsky #EMIMCC
academic.oup.com/cid/article/...
The innate immune protein calprotectin ablates the bactericidal activity of ฮฒ-lactam antibiotics
Jonathan Ryder, MD
VuMedi Infectious Disease
Clinical Infectious Diseases
Clinical Infectious Diseases
Antibiotic Steward ๐ ฑ๏ธC๐๐ ฟ๏ธ๐
Open Forum Infectious Diseases
Kyle T. Enriquez
In this pragmatic randomized trial of 277 adults, vancomycin-free hours alive in the first 7 days of trial enrollment did not significantly differ between
ฮฒ-lactam antibiotics are among the most widely used treatments for bacterial infections, yet therapeutic failure is common even when no genetic resistance is detected. Understanding how host factors...
