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Want to know how homologous recombination defects are caused upon loss of BRCA2? Check out our recent efforts in uncovering this phenomenon just out in Science! www.science.org/doi/10.1126/...
What an exciting day for the lab at the Dutch Chromatin Meeting! Congrats to Ashutosh (a.k.a Vincent 😉)for winning the poster prize on 3D reorganization of stressed forks & Joanna for her fantastic talk on phase separation during replication stress. Proud of you guys! 🤩
We show that anti-recombinase FIGNL1 removes RAD51 in BRCA2 deficient cells causing homologous recombination defects and loss of FIGNL1 restores functional recombination in these cells. More on the mechanism in the manuscript.