Online now: TCR signaling via NFATc1 constrains IL-15-induced bystander activation of human memory CD8+ T cells
Review @natrevcancer.nature.com @stjuderesearch.bsky.social
Epigenetic regulation of T cell exhaustion in cancer
www.nature.com/articles/s41...
Feeling festive?
Why not deck the halls with @cvrinfo.bsky.social's papercraft #VirusSnowflakes and celebrate the science of viruses and the fight against viral diseases.
Download for free: cvr-engagement.co.uk/virus-snowfl...
#scicomm #sciart #decorations
A Consensus Statement in Nature Reviews Immunology clarifies the existing subset-based nomenclature for T cells. It also proposes an alternative modular nomenclature that is designed to be brief and flexible and to avoid ambiguity and unwanted implications. go.nature.com/3Xzfoqb #immunosky 🧪
Tissue-resident memory T cells that express TCF1 or ID3 exhibit stem-like properties and regulate memory heterogeneity and recall @sciimmunology.bsky.social @thedohertyinst.bsky.social
www.science.org/doi/10.1126/...
Tam, Cyster et al. identify GPR34 as a splenic cDC1 receptor that is required for efferocytosis and for the cross-presentation of apoptotic cell–associated antigen to CD8 T cells. rupress.org/jem/article/...
#InnateImmunity #inflammation
@hhmi.org
Kyoto University scientists converted ordinary T cells into stable regulatory T cells that can suppress autoimmune disease in mice.
This approach may enable personalized, targeted cell therapy for inflammatory diseases.
www.science.org/doi/10.1126/...
Halloween costumes to scare scientists (by @twisteddoodles.bsky.social) 🧪
Our DECEMBER ISSUE is live! Hepatic T cells, microbiome and pancreatic cancer, portal hypertension and cirrhosis, metabolic and alcohol-related liver disease and much more!
www.nature.com/nrgastro/vol...
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Antigen-specific and functionally stable Treg cells can be generated in vitro from effector/memory T cells for cell therapy of inflammatory diseases.
Memory CD8+ T cells can undergo TCR-dependent or -independent activation. Here, Lee et al. show that IL-15-induced bystander activation of human memory CD8+ T cells is suppressed by concurrent TCR signaling through NFATc1-AP-1 interactions. Furthermore, they validate a bystander activation gene set induced by IL-15 and decreased upon TCR stimulation.
dlvr.it
Transcriptional and epigenetic mechanisms governing T cell exhaustion substantially impact immunotherapy effectiveness. In this Review, Kang et al. outline epigenetic regulatory programmes that i...
