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A decade ago we showed that T-dependent IgM+ memory B cells (MBCs) that express CD80 and CD73 rapidly respond to a secondary Plasmodium infection (Krishnamurty, Immunity, 2016). Since then, post-doc Gretchen Harms Pritchard has been working out the cues that lead to the formation of these cells. ⤵️
🔬 From our June issue (rupress.org/jem/issue/22...): Image shows H&E staining of the distal colon in a WT mouse, from a study by @mengzelyu.bsky.social and Sonnenberg, "B7 costimulation antagonizes RORγt+ regulatory T cells and immune tolerance in the intestine": rupress.org/jem/article/...
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Bidirectional regulation by BACH2 coordinates systemic CXCR5- vs. CXCR5⁺ CD4⁺ T cell differentiation. New study from Andrew R. Schroeder, Fangming Zhu, Xianyou Xia, and Hui Hu (University of Alabama at Birmingham): rupress.org/jem/article/... See a video summary by Schroeder 📽️ youtu.be/Ohp4Rg3a418
Nasal CD4⁺ tissue-resident memory #Tcells provide cross-protective immunity to #influenza. From Nimitha R. Mathew, Davide Angeletti @angelettilab.bsky.social and colleagues rupress.org/jem/article/... 📘 From our Clinical #Immunology Collection 👉 rupress.org/jem/collecti... #FOCIS2026
ICYMI: read the JEM #Cancer Collection highlighting the latest discoveries in the field of cancer #immunotherapy, anti-tumor #immunity, cancer #metabolism, #metastasis, and therapy resistance. 👉 rupress.org/jem/collecti...
Rab5 improves #CARTcell efficacy via reducing fratricide and maintaining surface CAR levels. From Meidi Gu, James L. Riley (@jimriley52.bsky.social) and colleagues: rupress.org/jem/article/... 📘 From our Clinical #Immunology Collection 👉 rupress.org/jem/collecti... #FOCIS2026
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📽️ New video summary of a study "BCL6 is required for the development of functionally responsive IgM+ GC Tfh–independent memory B cells" from the @marionpepper.bsky.social lab (rupress.org/jem/article/...) Video by the first author, Gretchen Harms Pritchard:
Transcription of #HIV-1 is heterogenous among authentic latent CD4+ T cell clones, say Cintia Bittar, Michel C. Nussenzweig and colleagues: rupress.org/jem/article/... 📘 From our Clinical #Immunology Collection 👉 rupress.org/jem/collecti... #FOCIS2026
IgD from atypical-like memory #Bcells and #plasmacells targets commensal and environmental antigens. From @rosertp.bsky.social, Bashour, Filipska, @victorgreiff.bsky.social, Cerutti et al rupress.org/jem/article/... 📘 From our Clinical #Immunology Collection 👉 rupress.org/jem/collecti... #FOCIS2026
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Marion Pepper
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Harms Pritchard, @marionpepper.bsky.social et al. dissect key CD4⁺ T cell/B cell interactions to define signals that govern the development of memory B cell populations. rupress.org/jem/article/... #InfectiousDisease #HostDefense #LymphocyteBiology #BCells
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Original paper: https://rupress.org/jem/article/223/8/e20252336/282726/BCL6-is-required-for-the-development-of Video summary by Gretchen Harms Pritchard (Marion Pepper lab, University of Washington)…
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BCL6 is required for development of functionally responsive IgM+ GC Tfh independent Memory B Cells