Studying immune gene evolution is rarely about a lack of data, it’s about keeping data, biology, and interpretation aligned as everything changes.
New GLUE Genomics post: from viral genomes to immune genes, using interferon lambda as a case study.
gluetools.substack.com/p/glue-resou...
gluetools.substack.com
Comparative Genomics Across the Host–Pathogen Interface
Now live! Nearly all human genes contain multiple transcript isoforms - and the genes that predominantly control infection, ISGs, are no different. Using PacBio with analysis help from Yan Guo, Himadri noticed a never-before-seen transcript isoform of ISG15 that potently restricts flu 1/4
www.biorxiv.org
Steve Baker
Excited to share our work on #AncientRNA from alcohol-preserved lungs, recovering the oldest human RNA virus genome (an 18th-century rhinovirus). Our study shows that viral RNA remnants persist in centuries-old tissue, opening new ways to study virus evolution and historical disease #Paleovirology🫁🦠
SMBE2026 Symposium 13 | Perspectives on paleo-omics: defining functional evolution of ancient viruses in the era of big data
📨 Abstract submission
smbe2026.org/abstracts
📋 Programme details
smbe2026.org/programme
#SMBE2026
www.biorxiv.org
Lovely to work with @blevinske.bsky.social, @paleogenomics.bsky.social & Verena Schuenemann on " Ancient DNA insights into diverse pathogens and their hosts"! Read it at rdcu.be/eSVPN
Happy to see @joelrc.bsky.social's paper identifying cellular heterogeneity in basal OASL expression as a major determinant of interferon induction during influenza virus infection out in its final form:
www.pnas.org/doi/10.1073/...
Happy new year, hope everyone's 2026 is better than 2025!
Society for Molecular Biology and Evolution
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
Nature Reviews Genetics - Ancient DNA techniques are being applied to study increasingly diverse pathogens of the past. The authors review the latest insights into pathogen–host coevolution,...
Standing ovation to @eeb222.bsky.social for powering through the many intricacies of this project. And huge thanks to @paleogenomics.bsky.social @jonploug.bsky.social JT McCrone, Mike Rutherford, Kathryn Kistler, Ale Castillo, Isabelle Du Plessis, @lauracarrillo.bsky.social & Ting Liu #ThankYouTeam💪🏼
