Looking to hire a postdoctoral associate to examine how antibiotics frequently fail in vivo and identifying new ways to make them work better. unc.peopleadmin.com/postings/306...
Discovery of a new class of natural antibiotics with a new mode of action to address antimicrobial resistance, a major unmet need
@mcmasteruniversity.bsky.social
@nature.com
www.nature.com/articles/s41...
Kash lab at UNC is hiring a new technician (our current two are off to grad school!!) posting will go live soon, email me CV and names of references if interested.
Congratulations to MD-PhD student, Amanda Velez and all co-authors on our new PNAS paper describing how the innate immune protein calprotectin incapacitates autolysins, inducing tolerance to B-lactam antibiotics. A fun collaboration with Thomas Kehl-Fie. www.pnas.org/doi/10.1073/...
Delighted to share our latest paper - A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics. Excellently led by Dr. Kuan-Yi Lu. We think it's a great proof-of-concept that altering immune cell behavior can make antibiotics work better www.nature.com/articles/s41...
For our first post on Bluesky, we're excited to share our recent work published in mBio @asm.org! Led by PhD student @madeofmicrobes.bsky.social, we show that flagellar motility and interactions with the mucus environment influence Pseudomonas antibiotic tolerance.
journals.asm.org/doi/10.1128/...
Come join us in Knoxville!
The Dept. of Microbiology 🧫🦠at the University of Tennessee is hiring 2 Assistant Professors (tenure track, 9-month appt.).
Microbial Drivers of Chronic Disease: apply.interfolio.com/173153Quantitative Microbe-Plant-Environment Interactions: apply.interfolio.com/173345
Excited to share the work with @dweisslab.bsky.social‬ and great collaborators on how gene amplification generates dynamic heteroresistance to new beta-lactams, like cefiderocol. We hope drug developers will consider heteroresistance during antibiotic development rdcu.be/euijW
Research shows: Rifaximin prophylaxis drives resistance to daptomycin, an unrelated, last-resort antibiotic
Rifaximin is used for hepatic encephalopathy in liver patients at high risk for infections, including VRE treated with daptomycin. The antibiotic was thought to pose a low resistance risk
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
The authors developed a screen to find compounds that modulate intracellular Staphylococcus aureus metabolism and discovered KL1, which sensitizes persisters to antibiotics by reversing host-induced tolerance.
www.nature.com
This Postdoctoral Research Associate will be involved with advanced independent biomedical research, including project development, experimental design and performance, data analysis, written progress...
unc.peopleadmin.com
A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistanc...
Antibiotic treatment failure of Pseudomonas aeruginosa infection is a key driver of mortality in muco-obstructive airway diseases (MADs).
The bacterial mechanisms that contribute to antibiotic toleran...
Nature Communications - Choby et al. show that dynamic increases in the copy number of preexisting β-lactamase genes in heteroresistance enables resistance of continua of cellular...
rdcu.be
Rifaximin use, particularly in patients with liver cirrhosis, may be compromising the clinical use of daptomycin.
