Discovery of a new class of natural antibiotics with a new mode of action to address antimicrobial resistance, a major unmet need
@mcmasteruniversity.bsky.social
@nature.com
www.nature.com/articles/s41...
Come join us in Knoxville!
The Dept. of Microbiology 🧫🦠 at the University of Tennessee is hiring 2 Assistant Professors (tenure track, 9-month appt.).
Microbial Drivers of Chronic Disease: apply.interfolio.com/173153Quantitative Microbe-Plant-Environment Interactions: apply.interfolio.com/173345
Delighted to share our latest paper - A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics. Excellently led by Dr. Kuan-Yi Lu. We think it's a great proof-of-concept that altering immune cell behavior can make antibiotics work better www.nature.com/articles/s41...
Congratulations to MD-PhD student, Amanda Velez and all co-authors on our new PNAS paper describing how the innate immune protein calprotectin incapacitates autolysins, inducing tolerance to B-lactam antibiotics. A fun collaboration with Thomas Kehl-Fie. www.pnas.org/doi/10.1073/...
Looking to hire a postdoctoral associate to examine how antibiotics frequently fail in vivo and identifying new ways to make them work better. unc.peopleadmin.com/postings/306...
Excited to share the work with @dweisslab.bsky.social and great collaborators on how gene amplification generates dynamic heteroresistance to new beta-lactams, like cefiderocol. We hope drug developers will consider heteroresistance during antibiotic development rdcu.be/euijW
Research shows: Rifaximin prophylaxis drives resistance to daptomycin, an unrelated, last-resort antibiotic
Rifaximin is used for hepatic encephalopathy in liver patients at high risk for infections, including VRE treated with daptomycin. The antibiotic was thought to pose a low resistance risk
For our first post on Bluesky, we're excited to share our recent work published in mBio @asm.org! Led by PhD student @madeofmicrobes.bsky.social, we show that flagellar motility and interactions with the mucus environment influence Pseudomonas antibiotic tolerance.
journals.asm.org/doi/10.1128/...
www.pnas.org
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
The authors developed a screen to find compounds that modulate intracellular Staphylococcus aureus metabolism and discovered KL1, which sensitizes persisters to antibiotics by reversing host-induced tolerance.
www.nature.com
Antibiotic treatment failure of Pseudomonas aeruginosa infection is a key driver of mortality in muco-obstructive airway diseases (MADs).
The bacterial mechanisms that contribute to antibiotic toleran...
A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common resistanc...
www.nature.com
Rifaximin use, particularly in patients with liver cirrhosis, may be compromising the clinical use of daptomycin.
Nature Communications - Choby et al. show that dynamic increases in the copy number of preexisting β-lactamase genes in heteroresistance enables resistance of continua of cellular...
rdcu.be
This Postdoctoral Research Associate will be involved with advanced independent biomedical research, including project development, experimental design and performance, data analysis, written progress...
Kash lab at UNC is hiring a new technician (our current two are off to grad school!!) posting will go live soon, email me CV and names of references if interested.
