Fascinating research! Qi Chen and colleagues have identified a potential "aging cliff" in sperm RNA (rsRNA) that is associated with the increased health risks for the next generation that accompany advancing paternal age. Read on uofuhealth.utah.edu/newsroom/new...
Perhaps the most puzzling part:
We see a paradox: the rsRNA length shift is progressive⏳yet the global RNA profile shows an "Aging Cliff"📉.
Cliff or Progression? Maybe the gradual shift is the forerunner—accumulating silently until it triggers the cliff.
bsky.app/profile/qich...
Perhaps the most puzzling part:
We see a paradox: the rsRNA length shift is progressive⏳yet the global RNA profile shows an "Aging Cliff"📉.
Cliff or Progression? Maybe the gradual shift is the forerunner—accumulating silently until it triggers the cliff.
bsky.app/profile/qich...
What underlies the impact of sperm aging on fertility and offspring health?
small ncRNA profiling by Kenneth Aston, Tong Zhou, @qichen-lab.bsky.social and colleagues reveals a drastic shift in RNA complements able to affect recipient cell metabolism
link.springer.com/article/10.1...
After years of crystallization, in @natbiotech.nature.com,
@zernickagoetz.bsky.social and I discuss the evolutionary origins of multicellularity & how physical constraints inevitably drive cellular self-organization. Harnessing these rules may help us better understand & engineer life rdcu.be/flTKa
Decoding the origins of cellular self-organization for engineered biology - @qichen-lab.bsky.social @zernickagoetz.bsky.social go.nature.com/4e1m3Br
A molecular "aging clock" has been identified in human sperm RNA, showing progressive changes with age that may influence offspring health and metabolism. doi.org/hbkmvf
Qi Chen
This Perspective positions cellular self-organization as a foundational principle for the origin of multicellular life and discusses how decoding this concept with stem cell-based models will advance ...
Perhaps the most puzzling part:
We see a paradox: the rsRNA length shift is progressive⏳yet the global RNA profile shows an "Aging Cliff"📉.
Cliff or Progression? Maybe the gradual shift is the forerunner—accumulating silently until it triggers the cliff.
bsky.app/profile/qich...
Qi Chen
1/5 It took us some time to connect the dots...now in @embojournal.org we use PANDORA-seq to start decoding the 'sperm RNA code of aging'
We find a conserved rsRNA length shift that reflects aging in both mouse & human sperm, and an 'aging cliff' at mid-life🧵
link.springer.com/article/10.1...
1/5 It took us some time to connect the dots...now in @embojournal.org we use PANDORA-seq to start decoding the 'sperm RNA code of aging'
We find a conserved rsRNA length shift that reflects aging in both mouse & human sperm, and an 'aging cliff' at mid-life🧵
link.springer.com/article/10.1...
1/5 It took us some time to connect the dots...now in @embojournal.org we use PANDORA-seq to start decoding the 'sperm RNA code of aging'
We find a conserved rsRNA length shift that reflects aging in both mouse & human sperm, and an 'aging cliff' at mid-life🧵
link.springer.com/article/10.1...
Qi Chen
Qi Chen
Qi Chen
link.springer.com
Sperm aging impacts male fertility and offspring health, highlighting the need for reliable aging biomarkers to guide reproductive decisions. However, the molecular determinants of sperm fitness durin...
