Perhaps the most puzzling part:
We see a paradox: the rsRNA length shift is progressiveā³yet the global RNA profile shows an "Aging Cliff"š.
Cliff or Progression? Maybe the gradual shift is the forerunnerāaccumulating silently until it triggers the cliff.
bsky.app/profile/qich...
Qi Chen
1/5 It took us some time to connect the dots...now in @embojournal.org we use PANDORA-seq to start decoding the 'sperm RNA code of aging'
We find a conserved rsRNA length shift that reflects aging in both mouse & human sperm, and an 'aging cliff' at mid-lifeš§µ
link.springer.com/article/10.1...
