Highly enjoyable Conversation article about a brilliant new neural tube paper:
theconversation.com/fluorescent-...
A lateral tension model for cranial mouse neural tube closure https://www.biorxiv.org/content/10.1101/2025.05.15.654327v1
One for #NeuralTube biologists:
Fascinating work on the biomechanics of mesenchymal tissues right here:
Gabriel Galea
#ApicalConstriction and #DevBio afficionados - we've got two new pre-prints you may be interested in, below:
2. iPSC neuroepithelial models by @hpscenthusiast.bsky.social identifying a patient mutation in VANGL2 which diminishes apical constriction in this human model
www.biorxiv.org/content/10.1...
In @eLife.bsky.social: Patient-specific iPSC models of neural tube defects identify underlying deficiencies in neuroepithelial cell shape regulation and differentiation doi.org/10.7554/eLif...
@hpscenthusiast.bsky.social
Delighted with this new paper. Key findings I'm most interested in following up:
- Mechanical cues impact cell shape long after the cue ends,
- Surface ectoderm (SE) cells have cryptic lamellipodia which may enable collective crawling,
- SE becomes progressively jammed
www.cell.com/current-biol...
1. Laser ablation study of the mouse cranial neuroepithelium, led by Juana de la O in Adam Martin's lab (MIT), identifying regional differences in apical tension and anisotropy in the lateral neural folds (consistent with a recent paper from Eric Brooks' lab)
www.biorxiv.org/content/10.1...
