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Oxytocin receptors increase in adipocytes during lactation in mice. 🍼 🧪 In Cell Metabolism, team reports that oxytocin stimulation of adipocytes then stimulates lipolysis and release of triglycerides into breast milk, where they're necessary to support mouse infant growth: https://ow.ly/3bzv50ZchXm

Overjoyed to be recognized today in such a profound way.

Firearms remained the leading cause of child (age 1-19 yrs old) death in the US from 2018-2023, per study in NEJM.org. “Public health measures to prevent deaths from firearm-related injuries, motor vehicle collisions, & drug poisoning remain crucial,” the authors wrote: https://ow.ly/gA7850Zb7il 🧪

In a 14-yr, $200M effort, the @alleninstitute.org initiative called the Brain Health Accelerator aims to capture earliest cellular damage underlying neurodegenerative disease & identify new drug targets. AI will help collaborators analyze datasets from 1000s of postmortem brains, per @science.org. 🧪

“Use your education to redesign our care delivery system so that it is truly a healthcare system, not a sick care system,” I encouraged grads yesterday during the Icahn SOM Master’s Commencement. Congrats to all grads—& may you always embrace evidence-based decision making to empower patients. ❤️‍🩹🧪

🧪In a trial in NEJM.org, scientists tested oral ensitrelvir for Covid postexposure prophylaxis vs. a placebo. Ensitrelvir administered to household contacts of a patient with Covid within 72 hours after symptom onset was effective in preventing Covid in contacts: https://ow.ly/2Tvx50Zb7So

Malaria may leave lasting effects on the brain, study in JAMA shows. Children who survived severe malaria scored worse on cognitive tests many years after infection, w/ a 4-7 pt IQ deficit vs controls. "It’s in the whole world’s interest to prevent this," one expert said: https://ow.ly/HCO750Z8SIE❤️‍🩹🧪

🧪Among ~64K scientists whose careers spanned ≥40 yrs, researchers found that the probability of producing a top 10% disruptive paper declines sharply with career age. The findings, in Science Magazine, suggest older scientists are less likely to overturn established ideas: https://ow.ly/3p7I50Z8R30

🧪 Taking a daily oral semaglutide reduced major adverse cardiovascular events by 14% in people with type 2 diabetes and CVD risk factors compared to taking a placebo, a trial in JAMA Cardiology found. Benefits to A1c, body weight, and blood & pulse pressure lasted >3 years: https://ow.ly/iKVz50Z8T4f

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Claire Pomeroy

Allen Institute initiative aims to capture earliest cellular changes and identify new drug targets

www.science.org

Brain-mapping effort searches for roots of Parkinson’s and other diseases

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🧪Cytokine gene therapy helped calm inflammation in infected lungs of mice, per study in Science Magazine. Viral-vector delivery of interleukin-2, IL-1 receptor antagonist, & IL-10 reduced tissue injury after respiratory infection, alleviating severe respiratory infections: https://ow.ly/aQAx50Z8SVV

We're thrilled to share that Lasker President Claire Pomeroy received an Honorary Doctor of Science Degree just hours ago from Mount Sinai's Icahn School of Medicine! 🧪 #SciSky #MedSky

Claire Pomeroy

Albert and Mary Lasker Foundation