New work from our own Liberles Lab (liberles.hms.harvard.edu) demonstrates that vagal mechanoreceptors monitor the cardiac cycle and initiate a blood-volume-dependent reflex that defends the constancy of circulation www.nature.com/articles/s41...
A vagal reflex to blood volume changes in the heart involves PIEZO2 and helps to stabilize blood pressure in an upright posture and after blood loss.
