🚨🆕🧪🔬 Hyperglycemia 👊🏻 the brain hard 🧠🔥 Miao, Mohiuddin et al shows GLUT1 is essential for brain endothelial cell survival under high glucose, w/o it, cells lose homeostasis and barrier function yikes😧
#Neurovascular #Diabetes #Physiology
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Excited to share a new story that transformed how we think about membrane domains in the ER!
rdcu.be/eR7Cn
ER exit sites mediated by the COPII adaptor sec24D selectively recruit lipid raft-preferencing proteins for rapid ER export
Wondering what’s so new and exciting? Skytorial below!
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🚨🆕🧪🔬That “wild-type” Nav1.5 variant everyone’s been using may not be so WT after all. Melgari et al. reveal T559A causes loss-of-function ⚡️❌ decades of WT controls weren’t truly WT, time to double-check those studies🧐🧬
#IonChannel #Physiology #Reproducibility
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🚨🆕🧪🔬 Congrats to @abhiprabhat.bsky.social - dim light at night exacerbates cardiac autonomic neuropathy (CAN) in diabetic mice & CAN disrupts coupling between heart rate and body temp 🫀⏱️
#CardiacAutonomics #Diabetes #Circadian #Physiology #CardioSky
www.heartrhythmjournal.com/action/showP...
Organelles do NOT have a single uniform pH.
And if you think they must, because “protons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧵 1/n
🚨🆕🧪🔬 Not all gut-brain signals follow the clock🕒🥣 Arnold and colleagues show CCK receptors + signaling in vagal afferents stay steady across day & night 🌞🌙 despite circadian rhythms 🧠➡️🍽️
#GutBrainAxis #Circadian #Physiology #Neuroscience
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Checking out this talk from Shrishti Naidu from the University of Kentucky on sex differences in the cardiac transcriptome. Great session so far! #APS2026 #APSSummit
A new review summarizes the genetics, diagnosis, and treatment of long QT syndrome, a major cause of sudden death in young people. Risk stratification and genotype-guided therapy are essential. Learn more in a new Review Article: nej.md/44cxXnN
#MedSky #CardioSky
brian_delisle
Nature Communications - Through synchronized cargo traffic experiments, the authors explore the role of raft partitioning in ER efflux. Raft-preferring cargos show specific preferences for ER exit...
If you are at #AHA25 go check out Dr. Prabhat’s @abhiprabhat.bsky.social poster- where he identifies feeding behavior as a potential modifiable risk factor for regulating autonomic input to the heart- It is TODAY 11:30am-12:30pm (Central) MC.APB.04
eppro02.ativ.me/web/index.ph...
#heart #CardioSky
