Asst. Professor at UAB Pathology | T cells, aging, mitos, 🧠,🫀, ☕️, 🐭, 🔬, data vis | He/him | Views mine
Dan Tyrrell
another grant app sent off to the void. we collectively keep pumping these out. is there a point to this?
#ArterioVenousMalformation
#HereditaryHemorrhagicTelangiectasia
Endothelial Cell KLF4 hyperactivation➡️
⏫EC Proliferation
⏬EC PDGFB➡️
⏬NG2+PDGFRβ+ Pericyte investment on AVM lesion
Evidence from
1⃣🐭 Retina +BMP9/10 Ab +EC Alk1 or Smad4 KO
2⃣HHT2👤 Nasal mucosa
#THNO 2026
www.thno.org/v16p4905.htm
Smooth Muscle Cell Calcification (Cultured & in vivo +VitK+Warfarin) is associated Depletion of Hyaluronan
⏬HAS1 HAS2 TSG-6
⏫HAS3 Versican
Very interesting study! But some data needs to be scrutinized...🤔
#Biomol_MDPI 2026
www.mdpi.com/2218-273X/16...
Dan Tyrrell
NAMs?
Just because they’re artificial doesn’t mean they will function
I’ve never seen a woman driving a cyber truck
We now have 12,463 silhouettes on PhyloPic! Cant believe it took this long to get a Sacabambaspis. #sciart www.phylopic.org/images/a6428...
Even if real, it would still be a horrible looking blot
Our paper on examining sequence-structure-function relationships and constraints on protein evolution is now published! www.nature.com/articles/s41...
