#ArterioVenousMalformation
#HereditaryHemorrhagicTelangiectasia
Endothelial Cell KLF4 hyperactivation➡️
⏫EC Proliferation
⏬EC PDGFB➡️
⏬NG2+PDGFRβ+ Pericyte investment on AVM lesion
Evidence from
1⃣🐭 Retina +BMP9/10 Ab +EC Alk1 or Smad4 KO
2⃣HHT2👤 Nasal mucosa
#THNO 2026
www.thno.org/v16p4905.htm
Hao Yin
