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by @jimpick.com
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Check out our new publication, a collaboration with Giovanni Luchetti and Vishva Dixit @ Genentech. We show that the E.coli effector NleL inhibits intestinal epithelial cell extrusion after #inflammasome activation via degrading the kinases ROCK1 and 2!! www.nature.com/articles/s41... Explainer 1/8
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The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled ...
www.nature.com
Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion - Nature
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