FIRST post here on Bluesky - we’re excited to share that our large spatial transcriptomics study of the human dlPFC in schizophrenia is now available on bioRxiv📄: www.biorxiv.org/content/10.6... (1/9)
With this 🗺️, we provide spatial context for disease-associated genes, including genes involved in trophic-inhibitory signaling and stress- and immune-related pathways (3/9)
By integrating GWAS data🧬, we also connect spatial gene expression landscape to genetic risk architecture and find evidence for disrupted “neuron to non-neuronal” interactions that may contribute to cortical dysfunction in schizophrenia (4/9)
We sincerely thank #NIMH #NIGMS & @lieberinstitute.bsky.social for supporting this work and are deeply grateful to the donors and their families, whose generosity made this research possible.
Again, we’re very excited to share this work with the community and look forward what comes next 🤩 (9/9)
Using Visium + Xenium profiling, we generated an integrated spatial atlas 🗺️ resolving schizophrenia-associated transcriptional changes across cortical layers, cell types, and distinct microenvironments, including neuropil-, perineuronal net-, and neurovascular-enriched niches (2/9)
We’re also grateful to @martinowk.bsky.social, @stephaniehicks.bsky.social, @kr-maynard.bsky.social, #StephaniePage for their mentorship, supervision, and guidance, and to @lcolladotor.bsky.social , #ShizhongHan, and @nikosdaskalakis.bsky.social and their teams for their close collaboration 🙏 (8/9)