High-quality, topflight, and clinically impactful basic and translational research representative of all biomedical specialties and physician-scientists: https://insight.jci.org/
JCI insight
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Curing diabetes in mice without immunosuppression! doi.org/10.1172/jci....
Here, Seung K. Kim & team present a non-toxic conditioning regimen with very low-dose radiation that enables stable mixed hematopoietic chimerism and islet allotolerance.
How does vitamin uptake influence heart disease?
In our new JCI Insight paper, we show that disrupted vitamin uptake can lead to cardiomyopathy and that early supplementation can prevent progression. insight.jci.org/articles/vie...
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A strategy that destroys breast cancers in mice: doi.org/10.1172/jci....
ASCI member Eric J. Sorscher & team use ICIs in combination with an E. coli enzyme-based focal gene therapy to enhance tumor clearance and ablate tumor-supporting cells in the microenvironment.
From improvised to intentional: Re-Imagining the physician-scientist career path: doi.org/10.1172/jci....
ASCI member Kyu Rhee & colleagues discuss the physician-scientist career at its crossroads, drawing from the 2025 ASCI/AAIM/BWF Workshop.
JCI insight
How do lipoproteins become trapped in the arterial wall in type 2 diabetes?
doi.org/10.1172/jci....
Björklund et al. find the increased susceptibility of serum LDL particles to bind arterial proteoglycans is linked to their enhanced transvascular entrapment and atherosclerosis.
From earlier this week: This first-in-disease study supports the use of GLP-1 agonist in pulmonary vascular disease
Colm McCabe & team show the GLP-1 agonist exenatide causes acute relaxation of lung blood vessels in pulmonary arterial hypertension: doi.org/10.1172/jci....
ICYMI: Metformin holds promise in Huntington’s disease: doi.org/10.1172/jci....
Robert M. Friedlander & team report metformin regulates mitochondrial fission, reprograms deregulated metabolism in microglia, & controls microglial activation & inflammation in HD mice.
This first-in-disease study supports the use of GLP-1 agonist in pulmonary vascular disease
Colm McCabe & team show the GLP-1 agonist exenatide causes acute relaxation of lung blood vessels in pulmonary arterial hypertension: doi.org/10.1172/jci....
How do cancer cells remodel their endosomal system under nutrient stress?
doi.org/10.1172/jci....
This issue’s Cover features work by Peng et al. showing serum starvation drives extracellular vesicle biogenesis and determines tumor progression.
