signaling systems and protein circuitry. reimagining what cells can be. fun posts only. Assistant Professor:
@uwbiochem | Postdoc: @stanford @prakashlab | Ph.D.:
@ucsf Wendell Lim @CDI_UCSF
Scott Coyle
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Congratulations to Gautam Dey (EMBL) and Omaya Dudin (University of Geneva) for being awarded the EMBO Gold Medal 2026 in recognition of their outstanding contributions to the #LifeSciences in Europe! 🧪 https://www.embo.org/press-releases/embo-gold-medal-2026-awarded-to-gautam-dey-and-omaya-dudin/
How do cells tune PRC2 allostery? We find EZH2 Ser21-phos restrains PRC2 adoption of the compact active state. Loss of this restraint promotes H3K27me3, redistributes cPRC1, and impairs differentiation. New bioRxiv with @kasinath-lab.bsky.social & @garcialabms.bsky.social! tinyurl.com/4369kmh2
1/13 So excited to share our new preprint!! How do organelles pack together in a crowded cytoplasm? we know organelles interact via contact sites, but how does competition for space contribute to organelle morphology and interactions?
@wallaceucsf.bsky.social
www.biorxiv.org/content/10.6...
EMBO
The Lewis Lab
Thanks for visiting and sharing your amazing science with us! I'll always have a place in my heart for U2-U6, even if we mostly talked about DNA
First lab sampling expedition. Turns out we don't even need to leave campus to find delightful protists.
And now it's out! Happy that PNAS selected for the cover this SEM image snapped by @samjlord.bsky.social, one of the most evocative visualizations of Euplotes that I have ever encountered.
www.pnas.org/doi/10.1073/...
Stay tuned for what is shaping up to be some fascinating follow-up in the lab...
Congratulations to Sourav Agrawal, who was awarded a Louis and Elsa Thomsen Wisconsin Distinguished Graduate Fellowship from @uwmadisoncals.bsky.social! His research in the @cijilim.bsky.social Lab focuses on telomeres. Learn more: biochem.wisc.edu/2026/04/28/s...
Very excited that our discovery of Sms1 as the #MAPK #scaffold of fission yeast mating has just been published in @natcomms.nature.com!
@biology-unige.bsky.social
www.nature.com/articles/s41...
Mary Mirvis
Video
Join us for Zhejing (Maggie) Xu's Ph.D. thesis defense on May 11! As a member of the @cellraiser.bsky.social Lab, Xu studied how predatory protozoa adapt cell morphology to optimize feeding efficiency in response to environmental demands. Learn more: ipib.wisc.edu/2026/04/17/i...
Dipa Sashital
Ben Larson
Ben Larson
UW–Madison Department of Biochemistry
Boris Sieber
UW–Madison Department of Biochemistry
Agrawal is one of two CALS students awarded the 2026 Louis and Elsa Thomsen Wisconsin Distinguished Graduate Fellowship.
What could be more exciting than watching Euplotes scurry around under the microscope? How about adding some raptorial predation by supergiant cannibal cells?
www.biorxiv.org/content/10.1...
Video by Vittorio Boscaro.
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Video
Xu’s research in the Coyle Lab sought to understand how subcellular structures self-organize.
Thanks to Sudhir Kumar for hosting me at Iowa State today. I had a lovely visit to the Biomedical Sciences Dept. at their amazing vet school. Great to also catch up with Dipa Shashital, one of my RNA world friends. Once a splicing person, always a splicing person.
Ben Larson
Hiten Madhani
In the W-S lab's first preprint, we describe how genomic language models know something about RNA thermodynamics. Though we think this is cool, things get tricky!
A growing practice for interpreting LMs is to perturb input tokens, often called "Categorical Jacobian": 👇
