Archaea and bacteria reveal the ancient origins of another ‘eukaryotic’ complex. Membrane trafficking is old… check this out for an integrative approach showing how bioinformatics and computational structural methods marry with x-ray crystallography and cryo EM to reveal biology in all its beauty.🧶🧬
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COMMD proteins assemble into a heterodecameric ring in the Commander complex, which plays a role in endosomal membrane trafficking and signalling in eukaryotes. Here, Liu et al. identify COMMD-like pr...