Adult ID and Assistant Prof at UNMC | Former IUSM IM & Truman State | Abx Stewie, Infxn Prevention, Digital MedEd, Podcasts, Medical History, Reading Non-Fiction, Running/Cycling | Posts are mine
Jonathan Ryder, MD
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This was a truly multidisciplinary effort and cannot thank my co-authors enough. This was all inspired by a simple clinical question from @jeremytigh.bsky.social followed by a dive into the literature and it ran from there. @shawna-san.bsky.social, Sean Avedissian, @cortes-penfield.bsky.social et al
📣 New #Communicable drops Monday, 15 June!
Join hosts Josh Davis & Emily McDonald with guests Roger Lewis & Ian Marschner as they demystify Bayesian and frequentist statistical approaches in clinical trials, exploring key differences, common misconceptions, and surprising similarities. 🎙️
#IDSky
The clinical data of studies comparing doses is largely quite old and is fairly limited for various methodologic reasons, but generally shows similar outcomes between dosing strategies
We also look at the question of dosing these drugs in obesity, for which there is limited literature
Excited to share an article that I've long awaited to share seeking to answer: What is the right dose of cephalexin/cefadroxil for SSTIs?
We reviewed clinical studies & conducted PTA sims to elucidate this #IDSky @absteward.bsky.social
accpjournals.onlinelibrary.wiley.com/doi/10.1002/...
We also conducted PTA simulations and found its not too hard to achieve PTA for group A Strep across many dosing regimens, but its a bit harder to achieve PTA for MSSA at higher MICs, which is similar to what USCAST found
New in @cmijournal.bsky.social:
"Which trial do we need? Evaluating plasma microbial cell-free DNA in blood culture-negative infective endocarditis"
#IDSky @absteward.bsky.social
www.clinicalmicrobiologyandinfection.org/article/S119...
REMAP-CAP domain on oseltamivir vs no-antiviral for patients admitted at ICU with influenza is stopped due to potential harm!
90d mortality:
Oseltamivir=19.4% (62/319)
No antiviral=13.7% (17/124)
Last word for oseltamvir?
What’s the rationale for harm? #IDSky
www.remapcap.org/oseltamivir-...
MRSA death rates remain high⚠️. Combo daptomycin+ceftaroline may reduce mortality: 0 deaths vs 6 in monotherapy in a 40-patient trial🧪. More studies needed🔎.
F1 (and soon to be Chief Fellow) Alison Smith is first author with a bunch of UW peeps on this great look at universal screening for c auris.
Do current public health criteria for screening hit the mark? Maybe not…
academic.oup.com/cid/advance-...
UW Infectious Disease Fellowship Program
oh my fuck, pasteurize your milk
al capone did not put a boot on the neck of his local dairy union for kids to get sick from milk a century later
NEW: Regulators have linked Mark McAfee’s raw dairy farm to more than a dozen recalls and outbreaks that left hundreds of people ill.
“I’ve put a couple kids in the hospital,” McAfee said. “But here’s the thing: I’m a pioneer.”
