Developmental biology fascinated about the many (sur)faces/phases of epithelial morphogenesis: from mechanics to evolution.
https://www.bdr.riken.jp/en/research/labs/wang-yc/index.html
Yu-Chiun Wang
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New Preprint alert!🚨
Super excited to share my postdoc work now on BioRxiv.
How does PRC2 loss lead to developmental failures?
We combined rapid protein degradation with TLS embryoid models to uncover temporal and lineage-specific dependencies 🧬.
Preprint: doi.org/10.64898/2026.04.18.719361
Congrats @drsusanna.bsky.social @ditalialab.bsky.social for solving the puzzle of how evolving gradient turns into spatial threshold responses. A beauty and quantitative tour de force. Full of nostalgia reading it. Did propose a temporal model ~20 yrs ago in thesis w/o data. Was quite wrong, tho 😂
An aPKC rheostat induces apical contraction in response to epithelial stretching
www.biorxiv.org/content/10.6...
(1/15)
Thrilled to share new Evo-Devo work where we address the molecular, cellular & morphometric basis of an extreme axis segmentation program in the Japanese eel — an animal that forms 120 vertebrae.
Apply by May 20th to do research @mpi-cbg.de or @biohub.org.
For example, my lab is open to your #ideas that loosely align with the theme of the #evolution of #morphogenesis. The name of the game is #freedom. Join us to develop an independent research line. I provide support, mentoring & technology
This exciting paper is now out in PNAS: www.pnas.org/doi/10.1073/...
Glad to see this out in its final form!
www.nature.com/articles/s41...
What changed since the preprint? Wonderful experiments disentangling the effect of receptor binding vs tissue porosity on Nodal diffusion, plus one of the smoothest review experiences! Thanks @natcellbio.nature.com & reviewers 🙏
Fantastic to see this out. Possibly a harbinger for a new field to come: thermal cell biology? Congrats!
New Pre-Print Alert!
Evolving initial conditions: an alternative developmental route to morphological diversity
with Shannon Taylor and @jamesehammond.bsky.social
www.biorxiv.org/content/10.6...
We´re hiring a #PhD student - if you´re interested in combining genetics, cell biology and state-of-the-art imaging to study #epithelial tissue dynamics in #Drosophila, apply to the CiM-IMPRS PhD program by May 1st (see below)
Please RT
@uni-muenster.de
@sfb1348.bsky.social
www.biorxiv.org
Yu-Chiun Wang
Daniel MK Lee
Cell behaviors in multicellular organisms are coordinated via both diffusible molecules
and by signals based on direct cell–cell contacts. The mode...
Autorino et al. report a feedback loop between Nodal signalling and tissue phase transitions in zebrafish embryos. Nodal alters adhesion, triggering tissue rigidification and reduced porosity, which l...
