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Assistant Professor in Trinity College Dublin. A mitochondria and immunometabolism enthusiast. Views my own. 🇮🇪

RyanLab_TCD

📢 Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️ ⬇️ ⬇️ biomed.news/bims-imicid/... Interesting finding: Mitochondrial OXPHOS restricts SARS-CoV-2 replication #mitochondria

Does mitochondrial respiration in DCs just “fuel” activation? In our new @ScienceImmunology study, we show that #mitochondrial Complex I is a selective checkpoint for #antigen #cross-presentation in #DCs, especially #cDC1s www.science.org/doi/10.1126/... At: CNIC_CARDIO @inmunosky

16d

Identification of an STING inhibitor targeting the allosteric transmembrane domains

20d

RyanLab_TCD

3/n The successful candidate will gain hands-on experience across areas such as: 🧫 Primary macrophage culture 🧬 Molecular biology and genotyping 🔥 Inflammatory and infection-associated assays 📊 Metabolic and immunological readouts 🔬 A growing programme in mitochondrial immunometabolism

4/n The post is funded by a Wellcome Trust Career Development Award and would be particularly suited to someone to pursue a PhD. 📍 Location: Trinity Biomedical Sciences Institute, Trinity College Dublin 📅 Anticipated start: Flexible, ideally September 2026 ⏰ Closing date: 12 noon, 15 June 2026

📢 Last 2 weeks of #immunometabolism discoveries brought to you from EUROMIT 2026 in sunny Angers Saint-Laud ☀️ @biomednews.bsky.social ⬇️ ⬇️ ⬇️ biomed.news/bims-imicid/... biomed.news/bims-imicid/... Interesting finding: Monocyte infiltration induces CNS arginine catabolism to fuel neuroinflammation

5/n Please share widely — and do get in touch if you know someone who might be a great fit! For details on how to apply see below: my.corehr.com/pls/trrecrui... #ResearchAssistant #Immunology #Mitochondria #Immunometabolism #InfectionBiology #PrimaryMitochondrialDisease #TrinityCollegeDublin

🚨 We’re hiring! 🚨 1/n I’m excited to share that the Ryan Lab at Trinity College Dublin is recruiting a Research Assistant to join our new team in the School of Biochemistry and Immunology, based inTBSI.☘️ Please share widely and see below for app details ⬇️

2/n This is a great opportunity for an early-career researcher interested in mitochondrial biology or immunology. The role will initially focus on primary macrophages from mitochondrial disease models to understand how pathogenic mtDNA mutations reshape cellular metabolism and innate immunity.

23d

David Sancho

23d

New selection of papers on #Mitochondria in #Health & #Disease! 📚 biomed.news/bims-mitdis/... Mitochondrial l-2-hydroxyglutarate is a physiological [..] metabolite www.nature.com/articles/s41... @biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social @mito-news.bsky.social

23d

Chen et al. introduce Y-320, a potent allosteric STING inhibitor that uniquely binds to the transmembrane domain instead of the canonical binding pocket, thereby blocking STING activation and trafficking. Y-320 effectively improves acute kidney injury in mice, highlighting the therapeutic potential of targeting non-canonical STING sites.

Identification of an STING inhibitor targeting the allosteric transmembrane domains

dlvr.it

Cell Chemical Biology

17d

RyanLab_TCD