Check out this really cool preprint from my colleague Francisco!
Nathanael B. Kegel
Very interesting work: "Pseudouridine selects RNAs for extracellular transport"
www.biorxiv.org/content/10.1...
More information available under the post by @lizeshi.bsky.social:
bsky.app/profile/lize...
Now finally peer-reviewed and published in @springernature.com Experimental & Molecular Medicine (EMM)🥳:
www.nature.com/articles/s12...
Our story was published back-to-back with the intriguing paper by Kim et al.:
www.nature.com/articles/s12...
Huge thanks to all the people involved, especially the @hoeferlab.bsky.social and @nursedayilmaz.bsky.social for their contributions to this project. What a journey it was! ☺️
Nathanael B. Kegel
www.nature.com
Nathanael B. Kegel
Nathanael B. Kegel
Glycosylation, a process where sugars attach to molecules, is known to modify proteins and lipids. Recently, researchers discovered that RNA can also be glycosylated. This study explores the presence ...
(1/2) Excited to share our new paper in @rheumjnl.bsky.social.We show that soluble BDCA-2 is elevated in rheumatoid arthritis and boosts IFN-α responses via nucleic acid binding. #Rheumatology #Diagnostics @unimarburg.bsky.social
academic.oup.com/rheumatology...
Excited to share our preprint about proteins that we found in preparations of glycoRNAs now available on bioRxiv! #glycotime (1/9)
www.biorxiv.org/content/10.1...
Francisco Venegas-Solis
Recent discoveries show that RNA can be modified with sialylated glycans (termed glycoRNA), thus broadening our understanding of cellular glycosylation beyond traditional proteins and lipids. However,...
How are RNAs presented on the cell surface without any transmembrane domains? In our paper published at Molecular Cell @cp-molcell.bsky.social, we provide mechanistic insights into this pressing question. They form ternary complexes with RNA-binding proteins and heparan sulfate proteoglycans.
#glycotime We hope our b2b publications serve as a heads-up for the #glycoRNA community, and drive the field forward constructively. Links👇
Kim et al. rdcu.be/eP4GQ
@nathanaelbkegel.bsky.social Kegel et al. nature.com/articles/s12276-025-01575-1 (Stefan Bauer lab)
