Immunologist, working with Cantrell Lab. Interested in LOTS - focused on nutrient and metabolic control of the immune system. (opinions are my own)
Linda Sinclair
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2 new efforts: from Megan Teh on metabolism of CD8 Tcells in iron deficiency and why they love aspartate (+ @sarahdimeloe.bsky.social @lindavsinclair.bsky.social); & reviewing the strong influence of iron on immunity @joefrost.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
So cool to start the afternoon session with @plantophagy.bsky.social !! Here in the @autophagyuk and @UK_proteostasis meeting
I have a 3-year postdoc position available at University of Manchester for a mass spec expert in proteomics. The person will be involved in exciting projects in single cell proteomics, drug discovery and innate immunity - on timsTOF Ultra AIP & HF & Astral Zoom.
www.jobs.ac.uk/job/DQJ093/r...
What if Tregs are not a separate lineage, but part of spontaneously activated T cells?
In this work, we integrate this idea with our recent findings: Adult T cell leukemia (ATL) is not 'Treg cancer', challenging the current concept of Treg as a distinct entity.š§µ(1/4)
academic.oup.com/discovimmuno...
šØLast week's #immunometabolism findings
@biomednews.bsky.social š½š½š½
biomed.news/bims-imicid/...
Interesting paper:
Glucose-1-phosphate promotes compartmentalization of glycogen with the pentose phosphate pathway in CD8+ memory T cells
Special issue Immunometabolism and Beyond: from Liver to Brain!
European Journal of Immunology
Article types: reviews and research articles
Submission deadline 1 November 2025
Thanks to Nadja, Matteo and Bin for this wonderful opportunity!
#immunometabolism #EJI #CRC1292 #CRC355 #CRC156 #FZI
Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells #immunometabolism
www.nature.com/articles/s41...
Marina GarcĆa Macia
Sparwasser Lab
Matthias Trost
RyanLab_TCD
RyanLab_TCD
Nature Metabolism
Review @annualreviews.bsky.social @lindavsinclair.bsky.social @cantrell-lab.bsky.social
Protein Synthesis and Metabolism in T Cells
www.annualreviews.org/content/jour...
****2-NBDG does not measure glucose uptake****
Just your regular reminder of this fact š.
See the rigorous proof of this fact in @lindavsinclair.bsky.social 2020 paper.
This paper was 6 years ago!! Stop using 2NBDG to measure glucose uptake already š
pmc.ncbi.nlm.nih.gov/articles/PMC...
Assays to monitor the metabolic state or nutrient uptake capacity of immune cells at a single cell level are increasingly in demand. One assay, used by many immunologists, employs 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose ...
Iron is crucial for cellular metabolism, but its availability varies greatly within and between individuals and populations. This Review highlights how iron regulates innate and adaptive cellular and ...
Iron has been shown to be necessary for the activation and differentiation of CD8+ T cells. Here the authors investigate changes in CD8+ T cell metabolism in iron limiting conditions and find that asp...
www.nature.com
Summary. Despite extensive regulatory T cell (Treg) research, fundamental questions on in vivo dynamics remain to be answered. The current study aims to di
Nature Metabolism, Published online: 13 May 2025; doi:10.1038/s42255-025-01276-zKao et al. provide insight into the metabolic requirements of IL-17A-producing Ī³Ī“ Tācells, offering an actionable target to treat psoriasis by inhibiting fatty acid synthesis.
