Don't ignore the "contaminants" on your grids ! We noticed this filament while solving the S. sanguinis T4P structure during my PhD. It turned out to be an incredible eDNA-protease assembly: literally a suspension bridge of proteins & DNA ! 🌉 Happy to finally share this story.
#CryoEM #Microbiology
Robin Anger
New preprint. In S. sanguinis, a C5a peptidase-like protease (ScpH) polymerizes along eDNA, turning it into a catalytic biofilm scaffold.
Great work from @robinanger.bsky.social in our lab, with Pelicic lab @lcbofficiel.bsky.social
www.biorxiv.org/content/10.6...
