Postdoctoral Fellow in the Ubellacker Lab at Harvard T.H. Chan School of Public Health. Focused on studying ferroptosis, cancer signaling, and lymph metastasis.
Mario Palma
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For more than 100 years, Harvard Chan School has worked to build a world where everyone can thrive.
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A reminder that for next month’s BCDI in place of our regular discussion, we encourage you to attend the Cutter Distinguished Lecture @met-hsph.bsky.social by the great Scott Dixon!
See you there: Monday May 12, 2025, Kresge Building at HSPH, G1 auditorium, 12:00-1:00pm
A huge thank you to all co-authors, especially Nathan Reticker-Flynn @retickerflynn.bsky.social Stanford) and Jess @ubellackerlab.bsky.social for her incredible mentorship and support.
Be sure to also check-out complementary findings from the Pappagianokopolous Lab, also online today in Nature, targeting FSP1 in vivo in lung tumors! www.nature.com/articles/s41...
Excited to share my postdoctoral work, out today in Nature! www.nature.com/articles/s41...
We discovered that melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits melanoma progression.
Our team (hsph.harvard.edu/research/ube...) is excited to have contributed to the intranodal in vivo testing of the remarkable new compound, Fentomycin-1. Congrats to team Rodriguez et al. for the implications of this work in targeting ferroptosis in cancer. Check it out here!
Short on time wrangling research hurdles or just life in general? @mariopalma.bsky.social and @mariesabatier.bsky.social have you covered with this focused spotlight on Ueda et al.’s work in Nature Cell Biology on oxidative niches and cancer cell dissemination. Spotlight article here: rb.gy/zi8wj9
Join me in Boston October 6th for a 1-day conference on #mappingbiology to transform #cancertherapeutics. Register by September 25th to benefit from the complimentary (free) admission! Topics, speakers, and talk opportunities here: abcam.me/mappingbiolo...
@abcamofficial.bsky.social
Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.
www.nature.com
Melanoma cells that spread to lymph nodes depend on FSP1 to survive, revealing a new metabolic vulnerability. New study in Nature by @mariopalma.bsky.social @ubellackerlab.bsky.social and colleagues shows that blocking FSP1 triggers ferroptosis and suppresses tumor growth in lymph node metastases.
The ferroptosis suppressor protein FSP1 has a critical role in ferroptosis protection of tumours across multiple in vivo models and is linked to worse prognosis in human lung adenocarcinoma, suggestin...
