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In our latest collaborative work we identify a novel form of reversible fluconazole heteroresistance that is associated with variable islands of heterochromatin in clinical isolates of Cryptococcus neoformans. Thanks to all @ Allshire, Heitman Bicanic labs especially 1st author @ybecky.bsky.social
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The fungal pathogen Cryptococcus neoformans is estimated to cause approximately 180,000 deaths annually, primarily among immunocompromised HIV patients in resource-limited countries in central and sou...
Variable ectopic heterochromatin islands provide an alternative route to antifungal heteroresistance in Cryptococcus neoformans
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me