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Professor, University of Edinburgh. Science: epigenetics, variegation, heterochromatin, heteroresistance, resistance, bet hedging, fungal biology & pathogens. Pets: Airedale Terriers. Duolingo: 🇫🇷 level 61. Opinions here are my own
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me









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In our latest collaborative work we identify a novel form of reversible fluconazole heteroresistance that is associated with variable islands of heterochromatin in clinical isolates of Cryptococcus neoformans. Thanks to all @ Allshire, Heitman Bicanic labs especially 1st author @ybecky.bsky.social
AI is good at needling people, had me in stitches following this thread!
A big car park where the Darwin Building at King’s Building, University of Edinburgh used to be
UKRI ”We expect to have fully transitioned to the new model by the start of the 2027 & 28 financial year.” Worrying - so how long is the pause? More logical to continue current funding model while developing new one! Researchers with key skills will be forced out of science while funding is paused
A lot of interest in QED Science as an automated review system linked to preprint servers. All we need now is funding level for authors to be somehow linked to the overall score provided by the AI and we can do away with grant writing and grant reviewing and panels. Cut the bureaucracy in science!
Thanks to all involved in both labs for making this happen - well done!
Hot off the press - a letter from the Exec Chair of @ukri.org explaining his plans and in particular the financial position of STFC. It notes curiosity driven research is protected and will make up around half of UKRI spend over the coming period www.ukri.org/news/open-le...
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www.embopress.org/doi/full/10.... Our latest now online at EMBO Journal. Read if you are interested in how epimutations mediate antifungal resistance & how this might result in heteroresistance in human & cereal crop fungal pathogens. Big Thx & congrats to Andreas Fellas, Pin Tong & Alison Pidoux
www.ukri.org/news/open-le... So let’s fiddle while researchers, whose funding is paused, get burned because their current funding is in its last 12 months. Lack of clarity & transparency creates uncertainty. Researchers need to plan ahead, they can’t without application deadlines to work towards
Very upsetting to hear the sad news of Greg Hannon’s passing. I always enjoyed our far too few conversations we had over the years. He had an interesting and insightful perspective on any science being discussed. He will be missed. www.cruk.cam.ac.uk/news/in-memo...
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Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me
Greg was already a world-renowned scientist when appointed Director, and for the community, he was a visionary leader, a cherished mentor, and a singular force of nature whose influence shaped the research landscape.
www.cruk.cam.ac.uk
In Memoriam: Professor Greg Hannon (1964–2026) - Cancer Research UK Cambridge Institute
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me
Hetan Shah
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me
UKRI Chief Executive outlines changes to UKRI investment approach, addressing concerns about research funding and the financial position of STFC.
www.ukri.org
Open letter from Ian Chapman to research and innovation community