Check out our latest research, just published in Nature @nature.com
@molbiolau.bsky.social
@au.dk
Molecular basis of polyadenylated RNA fate determination in the nucleus
www.nature.com/articles/s41...
Biochemical, structural and cell biological analyses reveal that UAP56 (DDX39B) assembles with a TREX-2–like module that redirects non-functional polyadenylated RNAs from export to degradati...
Intrigued by a long-standing conundrum in small RNA biology—how nuclear Argonaute proteins silence transposons when they *need* target transcription for their own recruitment—we studied the piRNA pathway.
And found a hidden RNA-decay axis from Piwi to the RNA exosome.
Now published! We investigated how polyadenylated RNAs are targeted for decay in the human nucleus. www.nature.com/articles/s41... (1/5)
How do cells distinguish functional genetic messages from molecular noise? Researchers in Clemens Plaschka's lab at IMP, together with Julius Brennecke's lab at IMBA and collaborators at Aarhus University, reveal a new principle of gene regulation: https://www.nature.com/articles/s41586-026-10650-0
Clear winter atmosphere, busy orbit.
Full moon of 2026
Triangle Galaxy
Nebula and busy skies
Plaschka lab
Julius Brennecke
IMP
Andrii Bugai
Andrii Bugai
Andrii Bugai
Andrii Bugai
Andrii Bugai
RNA decay via the nuclear exosome is essential for piwi-mediated transposon silencing https://www.biorxiv.org/content/10.64898/2025.12.16.694471v1
