Scientist at Aarhus University (DK).
Alumni of the University of Helsinki (FI) and Kharkiv University (UA).
I study how genes are regulated at the level of RNA.
Andrii Bugai
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Nature research paper: Molecular basis of polyadenylated RNA fate determination in the nucleus
go.nature.com/4vr9d7c
Clear winter atmosphere, busy orbit.
Galaxies shots, crowded sky
Triangle Galaxy
Nebula and busy skies
Check out our latest research, just published in Nature @nature.com
@molbiolau.bsky.social
@au.dk
Molecular basis of polyadenylated RNA fate determination in the nucleus
www.nature.com/articles/s41...
Now published! We investigated how polyadenylated RNAs are targeted for decay in the human nucleus. www.nature.com/articles/s41... (1/5)
How do cells distinguish functional genetic messages from molecular noise? Researchers in Clemens Plaschka's lab at IMP, together with Julius Brennecke's lab at IMBA and collaborators at Aarhus University, reveal a new principle of gene regulation: https://www.nature.com/articles/s41586-026-10650-0
Intrigued by a long-standing conundrum in small RNA biology—how nuclear Argonaute proteins silence transposons when they *need* target transcription for their own recruitment—we studied the piRNA pathway.
And found a hidden RNA-decay axis from Piwi to the RNA exosome.
Biochemical, structural and cell biological analyses reveal that UAP56 (DDX39B) assembles with a TREX-2–like module that redirects non-functional polyadenylated RNAs from export to degradati...
