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🏅 Congratulations to Sandra Schmid (@czbiohub) on receiving ASCB’s 2025 E.B. Wilson Medal! This award honors distinguished researchers for far-reaching contributions to cell biology over a lifetime in science—an achievement Sandra exemplifies. #ASCB #CellBiology
9mo
Happy to share our latest publication, in which we show that the arrangement of nucleosomes around CTCF sites contributes to higher-order organisation of chromatin into TADs: www.embopress.org/doi/full/10....
Wow www.bbc.com/news/article...
Jon Chen @jonchenjk.bsky.social and Claris Chong's review of recent in situ cryo-ET chromatin studies and our opinion on an important future genomic direction is now published in Current Opinions in Structural Biology. www.sciencedirect.com/science/arti...
8mo
This is huge: “A drug that provides near-perfect protection against H.I.V. with shots just twice a year will be made available at $40 per patient annually in low- and middle-income countries, offering new hope… making lenacapavir a realistic choice in countries with constrained resources.”
7mo
2d
Really important development in improving contrast in the painfully low contrast images we get out of a cryo-TEM
8mo
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
www.bbc.com
2d
Huntington's disease successfully treated for first time
American Society for Cell Biology
Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...
Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social www.biorxiv.org/cgi/content/... @mrclmb.bsky.social @wellcometrust.bsky.social
www.nytimes.com
7mo
9mo
Philanthropies Strike a Promising Deal to Turn Back H.I.V.
Telomerase counteracts telomere shortening by repeatedly adding DNA repeats to chromosome ends. We identified the replication protein A (RPA) heterotrimer as a telomerase processivity factor critical ...
www.science.org
Human RPA is an essential telomerase processivity factor for maintaining telomeres
Correlative MS Imaging for cellular identification and analysis of in situ cryo-ET www.biorxiv.org/content/10.1101/2025.09.16.676641v1 #cryoEM