Assistant Professor at the University of Zurich.
🖥️ protein design, machine learning🤖, crystallography💎, cryoEM🔬. Avid weirdness connoisseur 🎩
Martin Pacesa
Amazing work from the Kellogg lab!! I had this kind of project in my very first 2022 professorship proposal and but never actually did it, super glad to see it can work in reality!!!
There's a growing concern that AI tools used to help produce innovative drugs could also make it easier to create new threats
go.nature.com/4fhtqXx
The preliminary program and registration is open for SwissPR 2026, happening in Basel at the Biozentrum on 30th June. Hear from @jpkbravo.bsky.social , Jonathan Schmid-Burgk, Julian Grünewald, @martinpacesa.bsky.social, and more. Register now at www.swisspr-symposium.uzh.ch/en.html
Years. Definitely years.
Scientists are debating whether to limit biological AI software to ward off threats.
European RosettaCon 2026 will bring together the field's leading voices in computational protein design, machine learning, and structural biology, for three days in Lisbon this October. Don't miss the window for early bird pricing by registering before it closes May 31.
Thread coming later but I think people will like this!! 2 million stability measurements plus a predictive model for deltaG (not ddG)
Martin Pacesa
pretty wild that the top de novo binder designs in the last three Adaptyv competitions have all used our library mosaic (and the underlying open source models) in different ways. hallucination approaches in general (especially @martinpacesa.bsky.social 's bindcraft) have proven very strong
🚨 Job Alert 🚨
In the Scientific AI Flagship @humantechnopole.bsky.social, with Philipp @3p1l.bsky.social Erdmann we are looking for: shorturl.at/Biavu
"...experience in ML and CV... reliable software systems that interact with [the] real-world..."
Look at the position and apply!
Repost please! 🙏
After a busy few weeks of binding assays, we're ready to release the results from the muni × Adaptyv TREM2 hackathon. 16 teams designed binders against TREM2 in a single day in San Francisco: 10 human...
Programmable DNA integration with New-to-Nature tools using Computational Protein Design [new]
creates simplified RNA-guided transposons by reconfiguring CAST machinery to interface with Cas9 for precise, robust DNA integration.
This Perspective discusses current challenges in macromolecular ensemble prediction and the infrastructure and methodological advances needed to overcome these barriers.
Happy to share our latest pre-print on the Druantia defense system.
We find that Type III Druantia uses a cooperative helicase-nuclease mechanism to sense and degrade replication-associated forked DNA structures.
www.biorxiv.org/content/10.6...
A🧵
Nick Boyd
Stephanie Wankowicz
Florian Jug
www.biorxiv.org
Students, if you’re thinking about dropping a note to that teacher or professor about what their class/project/mentorship has meant to you, but you worry it will be cringe or cheesy, let me just tell you they will coast on the fuzzy feelings prompted by that note for months, if not years
