Visualising heteroplasmic mitochondrial DNA variants in situ? Now out as #mtDNA-smFISH in @cp-devcell.bsky.social! We find purifying selection against pathogenic mtDNA variants through genetic bottlenecks in the germline and the developing brain. www.cell.com/developmenta...
Chandrasegaram et al. directly visualize mitochondrial DNA inside intact cells and
tissues and reveal how genetic cell-to-cell variability arises during development.
They show that somatic bottlenecks...
