"Not all those who wander are lost" JR Tolkien
#Clinicalresearcher #DrugDevelopment
#Clinicaltrials & Registration
🧬🔬📚🔎🦠🧫 📌
Melbourne 🇦🇺 Oxford 🇬🇧& 🏴 #MedSky🧪
TRAstonDrs
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This study identifies identifies how the #SARSCoV2 accessory protein ORF8 acts via a paracrine mechanism to reprogram macrophages, establishing a feedforward proviral circuit that accelerates severe #COVID 🫁 #pathology .
www.biorxiv.org/content/10.6...
journals.plos.org/plospathogen...
www.mdpi.com/1999-4915/15...
This study has also bridges a long-standing gap in understanding how immune cell & epithelial compartments interact to drive the diffuse, hyperinflammatory 🫁 injury characteristic of severe #COVID .
Plant-Based Diets, Ultra-Processed Foods, and Risks of Mortality and Major Chronic Diseases: A Prospective Cohort Study - The Lancet Regional Health – Europe www.thelancet.com/journals/lan...
Reflections.
A few moments by the canal.
#photography
@pkrugman.bsky.social “We have a term for enterprises that look successful because they keep drawing in new investors and keep drawing in new investors because they look successful. They’re called Ponzi schemes. And Elon Musk is basically a human Ponzi scheme.”
The death of human empathy is one of the first signs and the most revealing of a culture on the verge of sinking into barbarism.
Hannah Arendt
#Medsky🧪 #publichealth In 832 patients with rare genetic disease, a conclusive diagnosis was made for 160 patients (19.2%) with long-read genome sequencing and for 137 patients (16.5%) with standard-of-care testing…
PDF
www.nejm.org/doi/pdf/10.1...
Babies are never suicidal. Hard lives, not hard boiled eggs do that.
Brian Spellman
Life sometimes can be fluttering like a petal when the wind dance,
A fragile thing of light and air, caught up in time and chance.
It drifts across the open sky, without a map or guide,
And learns to trust the moving breeze,
and join the breathless ride.
The frame of life …
