Red blood cells don't always make their own heme - under stress, they scavange it from neighbors. Our new paper in @ScienceMagazine reveals a cell-nonautonomous heme acquisition pathway essential for erythroid hemoglobinization. #heme #erythropoiesis #anemia
www.science.org/doi/10.1126/...
Heme, an iron-containing cofactor, is synthesized in mitochondria by an eight-enzyme pathway. Although cells were thought to manage heme autonomously, more than 1000 proteins contribute to its product...
