What does it mean to study RNA at system scale? This perspective lays out a roadmap—from quantitative transcriptomics to integrative modeling—for how we measure, model, and ultimately manipulate RNA across biological systems #RNAbiology #SystemsBiology #Genomics #ComputationalBiology bit.ly/3POaGo9
RNA isn’t just regulated in time—it’s regulated in space. This review explores mechanisms of mRNA localization and localized translation, highlighting how spatial control shapes cellular function and specialization #RNAbiology #mRNAlocalization #GeneRegulation #CellBiology #RNAseq bit.ly/4eboUJF
How do we connect RNA structure to function? This review highlights new approaches to probe RNA structure across dimensions, linking structural features to RNA activity, interactions, and regulation in complex cellular contexts #RNAbiology #RNAstructure #Genomics #ComputationalBiology bit.ly/4sthgOt
RNA function is defined by its interactions. This review surveys cutting-edge methods to map protein–RNA and RNA–RNA contacts, outlining how we can now begin to reconstruct RNA interaction networks at transcriptome scale #RNAbiology #Interactome #RNAprotein #Genomics #SystemsBiology bit.ly/41KDfWl
Can we drug RNA? This review explores the landscape of RNA-targeting small molecules, highlighting strategies to identify binding sites, design ligands, and overcome challenges posed by RNA structural flexibility #RNAbiology #RNAstructure #ChemicalBiology #DrugDiscovery #Genomics
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How well can machine learning predict RNA secondary structure? This review surveys current approaches highlighting both impressive gains and key limitations in generalizability and interpretability #RNAbiology #MachineLearning #RNAstructure #ComputationalBiology #Genomics bit.ly/4spSj6s
What’s next for RNA biology at system scale? This editorial frames a shift toward quantitative, integrative approaches, highlighting advances in measuring, modeling, and manipulating RNA across biological systems #RNAbiology #SystemsBiology #Genomics #RNAseq #ComputationalBiology bit.ly/41hv9UJ
Nanopore direct RNA sequencing is redefining how we detect RNA modifications and damage—enabling long-read, transcriptome-wide views with minimal RNA handling. This perspective highlights DRS in probing the epitranscriptome #RNAbiology #Epitranscriptomics #Nanopore #RNAseq #Genomics bit.ly/4dx1lec
RNA doesn’t just encode information, it helps build cellular structure. This review explores how RNAs drive the formation of biomolecular condensates, shaping organization, regulation, and function across contexts #RNAbiology #PhaseSeparation #BiomolecularCondensates #CellBiology bit.ly/4mjjI8B
Excited to highlight the new Special Issue of RNA showcasing advances in system-level RNA biology, from epitranscriptomics and RNA damage to deep learning–driven structure prediction and beyond #RNAbiology #Epitranscriptomics #RNAseq #ComputationalBiology #Genomics bit.ly/4tEQL9I
