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These also could explain why AGOs need to accumulate water molecules inside. www.cell.com/molecular-ce...
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Park et al. present the crystal structure of human Argonaute4 bound to guide RNA, revealing water molecules that form two clusters and that tie together its converged domains to stabilize the bilobal ...
www.cell.com
Multidomain Convergence of Argonaute during RISC Assembly Correlates with the Formation of Internal Water Clusters