ASC Distinguished Professor / PI of the Nakanishi Lab https://u.osu.edu/nakanishilab/)/ I study tinyRNAs, cityRNAs and other small noncoding RNAs. https://twitter.com/ktr_nakanishi
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Now out @natbiotech.nature.com ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones.
Igor Ulitsky
These also could explain why AGOs need to accumulate water molecules inside.
www.cell.com/molecular-ce...
A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our Micah Goldrich and Louis Delhaye from
Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...
