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New preprint from the last portion of my PhD! Despite low masked load, we found evidence for strong inbreeding depression in Devils Hole pupfish. The reason? A recessive lethal haplotype that causes a heart defect among developing embryos. www.biorxiv.org/content/10.6...
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I feel like this is me most of the time. 😑
As anthropogenic habitat fragmentation and population decline accelerate globally, growing numbers of species face compounding demographic and genetic threats to long-term survival. Many populations a...
www.biorxiv.org
Long-term small effective population size, inbreeding, and a recessive lethal haplotype drive premature death in the endangered Devils Hole pupfish (Cyprinodon diabolis)
Just saw David Tian give a great talk about this work at #PEQG26!
My heart!! ❤️
Sethuraman Lab posters tonight at #PEQG26: @jackwolfe27.bsky.social at 174T with the 1st genome of the SoCal native bebes - big-eared woodrats (Neotoma macrotis), & Alexandra at 392T, presenting our upcoming pangenome, & multi-omic approach to studying drought tolerance in hops (Humulus lupulus).
This year’s Genomic History Inference Strategies Tournament includes challenges in inferring relatedness. ghist.bio. If you haven’t worked in this problem before, here’s a great resource to help you get started.
Thanks to all the amazing folx that joined us tonight! WOW - what a turnout. I am so glad that we got to celebrate pride month here at #PEQG26 in our own cute way. Cheers!
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~15 years after we published the first chelonian genome (Chrysemys picta), I'm going back to my turtle roots! We now have an excellent assembly, annotation, & evo-history study for the spotted turtle (Clemmys guttata), led by the amazing @cheloevo.bsky.social, out in JOH: doi.org/10.1093/jher...
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Had the best time at #PEQG26 with my lab - thanks to @genetics-gsa.bsky.social for making it so special. Until next time ❤️
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doi.org
Abstract. The spotted turtle (Clemmys guttata) is the sole extant member of the genus Clemmys and can be found in shallow wetlands across eastern North Ame
An annotated, chromosome-level genome for the spotted turtle, Clemmys guttata
David Tian
Dr. Arun Sethuraman
Dr. Arun Sethuraman
Dr. Arun Sethuraman
Dr. Arun Sethuraman
Dr. Arun Sethuraman
Dr. Arun Sethuraman
Ryan Gutenkunst
Ryan Gutenkunst
Alright - time for some ad hoc meets at #PEQG26! LGBTQIA+ folx, meet after tomorrow’s poster sesh, around 10 pm by Hurst Social Hall fires (where you check in). I’ll bring some drinks (non alcoholic, alcoholic). Hope to catch up with all of you!
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