Why does IRE1 sometimes promote tumors and sometimes fight them?
We identify DPM1 as the rheostat controlling IRE1 activity. Low DPM1 sustains immunogenic IRE1 signaling, enhances CD8+ T-cell surveillance, and predicts better immunotherapy responses. www.nature.com/articles/s41...
Endoplasmic reticulum (ER)-stress signaling shapes tumor immunity, yet the underlying molecular mechanisms remain poorly defined. Here, the authors show that the glycosylation enzyme DPM1 regulates th...
