Check how this study shows that while prostasin deficiency does not affect primary tumor growth, it results in a significantly increased of metastasis due to the crucial role of fibronectin in tight junctions.
Check how this study uncovers a mechanism whereby FBP1 can be regulated by a protein O-GlcNAcylation-polyubiquitination axis, paving the way to cancer cell metabolic reprogramming and tumour progression in pancreatic cancer.
“O-GlcNAcylation of FBP1 promotes pancreatic cancer progression by facilitating its Lys48-linked polyubiquitination in hypoxic environments”
🔵 Interesting research led by Wei Feng was featured in #Oncogenesis.
▶️ Read the full open access article here: www.nature.com/articles/s41...
Oncogenesis
Oncogenesis
Oncogenesis
Check how this study suggests that combining stemness gene intervention with TKIs may be a viable approach for treating FLT3-ITD+ AML and other tyrosine kinase-mutated leukemias.
Check how their findings demonstrate that PRMT6-dependent EZH2 methylation plays an important role in driving breast tumour growth, revealing a new epigenetic mechanism of PRMT6 in the breast cancer and highlighting PRMT6 inhibition as a potentially therapeutic strategy.
happy to share our review collection “Metabolic Reprogramming in Cancer: Mechanisms and Therapeutic Opportunities” @oncogenesisnature.bsky.social . A big thank you to all contributing authors. If you are interested in cancer metabolism, I encourage you to read these expert reviews. enjoy!!
“PRMT6-mediated EZH2 arginine methylation is critical for breast cancer development”
🔵 Zhenhai Yu‘s latest research is now available to read in #Oncogenesis.
▶️ Read the full open access article here: www.nature.com/articles/s41...
Why does IRE1 sometimes promote tumors and sometimes fight them?
We identify DPM1 as the rheostat controlling IRE1 activity. Low DPM1 sustains immunogenic IRE1 signaling, enhances CD8+ T-cell surveillance, and predicts better immunotherapy responses. www.nature.com/articles/s41...
“Metastasis suppressing properties of the cell-surface anchored serine protease prostasin: new functional and mechanistic insights from breast cancer”
🔵 Karin List‘s latest research is now available to read in #Oncogenesis.
▶️ Read the full open access article here: www.nature.com/articles/s41...
Oncogenesis
Oncogenesis
Jean-Ehrland RICCI
“FLT3 inhibition upregulates OCT4/NANOG to promote maintenance and TKI resistance of FLT3-ITD+ acute myeloid leukemia”
🔵 Interesting research led by Yaming Xi was featured in #Oncogenesis.
▶️ Read the full open access article here: www.nature.com/articles/s41...
