New online: Semirandom DNA adducts regulate a filamentous defense-associated reverse transcriptase
Nature Structural & Molecular Biology, Published online: 10 June 2026; doi:10.1038/s41594-026-01813-8Neville et al. show that DRT1 synthesizes semirandom DNA adducts to stabilize a filamentous state. C-terminal pseudoknots form along the axis of the filament. The pseudoknot conformation inhibits a nitrilase domain, preventing abortive infection.
