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ICYMI: New online: Temperature and intrinsic Ca2+ reshape TRPM4 pharmacology
Nature Structural & Molecular Biology
New online: Temperature and intrinsic Ca2+ reshape TRPM4 pharmacology
New online: Semirandom DNA adducts regulate a filamentous defense-associated reverse transcriptase
ICYMI: New online: Distinct repair outcomes from single and convergent replication fork collapse
New online: Distinct repair outcomes from single and convergent replication fork collapse
ICYMI: New online: Semirandom DNA adducts regulate a filamentous defense-associated reverse transcriptase
New online: How cohesin guides DNA repair via scanning and tethering
New online: Yolk transports miRNAs to embryos and enhances progeny stress resilience
ICYMI: New online: How cohesin guides DNA repair via scanning and tethering
ICYMI: New online: Yolk transports miRNAs to embryos and enhances progeny stress resilience
Nature Structural & Molecular Biology, Published online: 27 May 2026; doi:10.1038/s41594-026-01812-9Here the authors show that collapse of single replication forks causes recombination, end fusions or degradation but does not restart DNA synthesis. In contrast, collapse of convergent forks completes DNA synthesis through error-prone double-strand break repair.
Nature Structural & Molecular Biology, Published online: 27 May 2026; doi:10.1038/s41594-026-01812-9Here the authors show that collapse of single replication forks causes recombination, end fusions or degradation but does not restart DNA synthesis. In contrast, collapse of convergent forks completes DNA synthesis through error-prone double-strand break repair.
Nature Structural & Molecular Biology, Published online: 02 June 2026; doi:10.1038/s41594-026-01815-6A broken chromosome must find an identical DNA sequence among billions of bases packed into the nucleus. Although homologous recombination solves this problem with remarkable accuracy, how the repair machinery locates the correct template within folded chromatin has remained unclear. Two recent studies show that cohesin’s loop-extruding and sister-chromatid tethering activities solve different parts of this search problem.
Nature Structural & Molecular Biology, Published online: 27 May 2026; doi:10.1038/s41594-026-01822-7This study shows that yolk, a conserved vehicle for nutrient provisioning to developing eggs, also transports regulatory small RNAs, such as microRNAs, from somatic tissues to the germline and embryos. This pathway links the maternal environment to inherited regulatory information and stress resilience in the next generation.
Nature Structural & Molecular Biology, Published online: 02 June 2026; doi:10.1038/s41594-026-01815-6A broken chromosome must find an identical DNA sequence among billions of bases packed into the nucleus. Although homologous recombination solves this problem with remarkable accuracy, how the repair machinery locates the correct template within folded chromatin has remained unclear. Two recent studies show that cohesin’s loop-extruding and sister-chromatid tethering activities solve different parts of this search problem.
Nature Structural & Molecular Biology, Published online: 27 May 2026; doi:10.1038/s41594-026-01822-7This study shows that yolk, a conserved vehicle for nutrient provisioning to developing eggs, also transports regulatory small RNAs, such as microRNAs, from somatic tissues to the germline and embryos. This pathway links the maternal environment to inherited regulatory information and stress resilience in the next generation.
Nature Structural & Molecular Biology, Published online: 09 June 2026; doi:10.1038/s41594-026-01818-3Hu et al. show that physiological temperature and intrinsic Ca2+ reprogram TRPM4 pharmacology, revealing hidden ligand activities missed under simplified assay conditions—even at structurally stable sites—and highlighting the need for environment-aware drug discovery.
Nature Structural & Molecular Biology, Published online: 10 June 2026; doi:10.1038/s41594-026-01813-8Neville et al. show that DRT1 synthesizes semirandom DNA adducts to stabilize a filamentous state. C-terminal pseudoknots form along the axis of the filament. The pseudoknot conformation inhibits a nitrilase domain, preventing abortive infection.
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Nature Structural & Molecular Biology, Published online: 09 June 2026; doi:10.1038/s41594-026-01818-3Hu et al. show that physiological temperature and intrinsic Ca2+ reprogram TRPM4 pharmacology, revealing hidden ligand activities missed under simplified assay conditions—even at structurally stable sites—and highlighting the need for environment-aware drug discovery.
Nature Structural & Molecular Biology, Published online: 10 June 2026; doi:10.1038/s41594-026-01813-8Neville et al. show that DRT1 synthesizes semirandom DNA adducts to stabilize a filamentous state. C-terminal pseudoknots form along the axis of the filament. The pseudoknot conformation inhibits a nitrilase domain, preventing abortive infection.
