New online: Rap1-mediated steric hindrance protects telomeres from MRX sensing
Nature Structural & Molecular Biology, Published online: 20 May 2026; doi:10.1038/s41594-026-01810-xThe authors show that Rap1 protein coverage protects telomeres by physically blocking the Mre11–Rad50–Xrs2NBS1 complex. Longer, denser Rap1 arrays better prevent DNA damage responses, providing a mechanism for how cells detect short telomeres and maintain genome stability
