New online: When membrane insertion sets the pace of mitochondrial translation
Nature Structural & Molecular Biology, Published online: 07 May 2026; doi:10.1038/s41594-026-01799-3Human mitochondrial ribosomes synthesize membrane proteins while docked at the inner membrane, but how insertion feeds back onto decoding has remained unclear. A recent study reveals that nascent-chain topology and early folding within the mitoribosomal vestibule modulate elongation speed, establishing kinetic checkpoints during respiratory chain biogenesis.dlvr.it
