Chemist using enzymes to build molecules. Chemo-enzymatic synthesis of modified nucleotides and investigation of modified mRNAs and other nucleic acids. Permanent scientist at the University of Münster, Germany. PhD from RentmeisterLab.
Nicolas Cornelissen
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A baby platypus is called a puggle (or 'platypup' 😁)
And anytime you post a video like this one, someone always points out they have venomous spurs.
The adult males DO, but *only* the adult males!
Let's talk about the amazing venom cocktail produced by this adorable little beaver-duck.
Video
c0nc0rdance
Last Saturday morning ☕ saved for this gem:
www.science.org/doi/10.1126/...
CRISPR screening reveals TRIM25 as a pH-sensitive sensor that specifically targets foreign RNAs entering through endosomes. N1-methylpseudouridine helps repel TRIM25 binding & enhances protein production.
Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens...
www.science.org
Join us! We are looking for a new team member (PhD student) with strong background in organic chemistry.
🙏 RETWEET (We want to recruit internationally)
Organic chemistry meets #DirectedEvolution
Highly interdisciplinary & passionate research group
uni-bielefeld.hr4you.org/job/view/433...
"So ein herrlicher Tag, und ich soll gehen. Aber was liegt an unserem Leben, wenn wir es damit schaffen, Tausende von Menschen aufzurütteln und wachzurütteln" (Sophie Scholl)
Heute vor 82 Jahren wurden Sophie Scholl, Hans Scholl und Christoph Probst von den Nazis ermordet.
Holidays with the family in and around Lisbon, where I lived for eight years 🎉🎉🎉
Join us as the first PhD student in my group! Based in the beautiful city of Münster, Germany, you will develop the chemo-enzymatic synthesis of modified nucleotides, which are used as building blocks of mRNA.
Here is the link:
stellen.uni-muenster.de/jobposting/6...
#chemsky #chembio
We systematically studied the substrate preferences of EbPPK2, determined the first crystal structure of the enzyme and used structure-guided engineering to enable efficient access to base-modified GTP and ATP analogues. #ChemSky #ChemBio
pubs.rsc.org/en/content/a...
Thanks to Rachel, @raschere.bsky.social, Ann-Marie, Jannik, Aileen, @rentmeisterlab.bsky.social and Daniel!
