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by @jimpick.com
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Last Saturday morning ☕ saved for this gem: www.science.org/doi/10.1126/... CRISPR screening reveals TRIM25 as a pH-sensitive sensor that specifically targets foreign RNAs entering through endosomes. N1-methylpseudouridine helps repel TRIM25 binding & enhances protein production.
Apr 5, 2025
Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens...
www.science.org
Exogenous RNA surveillance by proton-sensing TRIM25
Jordan Meier